Abstract: Since 2000, with the rapid development of China’s export-oriented economy and the deepening of Sino-US economic and trade cooperative partnership, the scale of China’s outward foreign direct investment (COFDI) in the United States has further expanded. By adopting the geographic concentration index and the spatial autocorrelation methods and taking 50 states and the District of Columbia as the research unit, this paper analyzes the spatial-temporal pattern evolvement and trend of COFDI in the United States from 2000 to 2014. The results are as follows: 1) The extent of unbalanced in geographical distribution of COFDI in the United States has declined, and the overall trend is gradually balanced. 2) There are significant differences of the level of COFDI between different regions in the United States. Specifically, the southern has larger scale while slower in increasing speed. On the contrary, the northeastern, the mid-western and the western have common scale and faster increasing speed. 3) The spatial distribution of COFDI in United States presents the trend of diffusion from coastal to inland, southern to mid-western. 4) On the whole, there is a weak spatial autocorrelation of COFDI in the United States. The degree of clustering is not significant, showing the spatial pattern as “cluster-random distribution-discrete”; and forming the differentiation of “hot zone” and “cold zone”.