Abstract: At first, the article defined the concept of metropolitan areas and urban agglomeration, emphasized that the urban agglomeration are based on metropolitan areas. Furthermore, using the nearly two censuses and the regional economic statistical yearbook of 2011 in china, carried out empirical research in Hubei, Hunan, Jiangxi and Anhui four provinces of the Middle Reaches of the Yangtze River. The results show that there are 22 metropolitan areas in the Middle Reaches of the Yangtze River region in 2010, there are 20 metropolitan areas in 2000. The Urban Agglomeration in the Middle Reaches of the Yangtze River consists of four small Urban Agglomerations, it is a cross axial along the Northeast southwest and northwest southeast, it is scattered overall and concentrated locally. Finally, according to the characteristics , we put forward four suggestions to develop the Urban Agglomeration in the Middle Reaches of the Yangtze River.