Abstract: Abstract: On the background of regional economic integration and eco-environment developing being researched as a popular topic, how to coordinate the two systems includes the sustainable development of a country or region. Especially the coupling and harmonious development is a key issue in the sustainable development. On the basic of 20 indicators of the two systems and through employing models of coordination degrees and method of weighted entropy value, the paper evaluates the regional economic integration level and eco-environment level from 1991 to 2010 at the national level. The result shows that the process of regional economic integration has being speeding up in the recent 20 years, the level of ecology and environmental reveals a general fluctuation trend of “one up and one down and one up”. While the coupling and coordinated degree has achieved the stable and continuous improvement. In the provincial research scales, the paper analyzed the regional economic integration and eco-environment coupling and coordinated development in China’s 31 provinces in 1991, 2000, 2010 at the time-space dimensions. The results show that the levels of regional economic integration and eco-environment systems and the coupling degree exist obvious regional difference.