Abstract: As urbanization speeds up in China, more and more Muslim women moved into coastal megacities. Existing study has investigated Muslim women’s social integration in cities and its impact factors, but seldom from the perspective of activity spaces. Based on questionnaire survey and in-depth interview in Guangzhou, the current study analyzed the characteristics and evolution of Muslim women’s social integration, as well as the effects of activity space expansion. The results show that Muslim women’s social integration is mainly manifested in four aspects: they win higher scores in economic and social integration and psychological adaptation, not too bad in daily life adaptation, but relatively backward in cultural integration. Along with their residence in Guangzhou, Muslim women’s activity spaces extend from certain original anchors to the main urban activity spaces, and finally shows little difference from the local residents’. Wide activity spaces, as well as abundant and various facilities around main activities, will significantly improve Muslim women’s social integration in the city.