Abstract: As one of the Asian Tigers, Singapore rethought its strategies for economic after the Asian Financial Crisis and began to develop knowledge-based economy. In recent years, the government introduced a series of measures and facilitated Singapore’s innovation by attaching great importance to the innovative development of manufacturing and services, encouraging entrepreneurship, creating innovation environment, cultivating and introducing the talents, mo tivating the researchers in technology transfer, creating platform for innovation and improving local innovative capability. Singapore has turned into a knowledge-based innovative city and became the innovative hub of Southeast Asia, the experience of its development is instructive to Shanghai who is preparing to build innovation centre. Based on analyzed Singapore’s background of innovative city, the article discussed its policies, in order to provide a reference for Shanghai.