Abstract: Establishment of Free Trade Zones will have huge impacts for China’s opening up and to enhance the connection between china and the world economy. It will also help Chinese government to face the challenge from U.S. Trans -Pacific Partnership Agreement and to accelerate the negotiations of China-U.S. Bilateral Investment Treaty. U.S. have world’s biggest FTZ system which covers 270 FTZs over the country. U.S. FTZs’ development have experienced four stages form initial to booming period over 80 years. Most of U.S. FTZs are located by coastline or along the river side, and some of the FTZs are located at the border of states or countries.FTZ General-Purpose Zones are trade-oriented and most of them are located at east coast, FTZ Sub-zones are manufacture-oriented and most of them are located at the Gulf of Mexico. FTZ cluster can be found around NewYork, Seattle, Florida, Gulf of Mexico and Great Lakes. China and U.S. are similar on the landscape, coastline and population, and through the study on comparison between U.S. and Chinese FTZs’ function and spatial distribution and its evolution, we found both countries would like to establish FTZs along coastlines and rivers while FTZ cluster spreading over the country. In the future, Chinese Bonded Harbors and Comprehensive Bonded Zones will transfer into FTZs and will spread into inland china by railroad. FTZ cluster will accelerate along east coastline and Yangtse River and Yellow River.