Abstract: Guizhou province is one of the poorest province with the most extensive area of poverty. It is of typical significance to analyze the poverty factors in contiguous destitute areas. This paper using grey relational analysis carried on quantitative analysis of correlation between poverty and the influential factors, such as natural environment conditions, labor population quality, production inputs and employment transfer. The result showed that the influential degree of four factors on poverty of Guizhou contiguous destitute areas was labor population quality, natural environment conditions, production inputs, employment transfer in turn. And it targeted proposed anti-poverty related suggestions.