Abstract: With the globalization of tourism activities, the consumption behavior of cross-cultural tourists become a hot academic topic since 1970s. Uzbekistan is an integral link between east and west which is the gold node of the ancient silk road. Draw upon the Hofstede(1983)'s dimensions of national cultures, this paper compares the differences of inbound tourists' behaviors and perceptions in Uzebekistan and analysis its implications to the development of Silk Road. The study finds that: 1. Culture has important effects on tourists’ travel behaviors and perceptions. Tourists in different cultural category have significant differences in visiting purposes, travelling patterns, length of stay and visiting spaces. 2. Inbound tourists in Uzebekistan are commonly rich senior citizens. They are well-educated and pursue for authenticity and indepth travelling experiences. 3. Due to the cultural differneces, the Western tourist generally prefer cultural experiences and appreciation of the historical buildings; the Russians pay more attention on secular experience of food and health; the Asians care more on the historical relationships related to themselves, cultural values of visiting sites and service quality. These findings have important practical implication to the development of Silk Road tourism to impetus the bilateral cooperation between China and Uzebekistan.