Abstract: Taking the infrastructure and urbanization as the measuring indicator, this paper analyses the spatiotemporal pattern, spatial correlations and impact factors of the coordination development of infrastructure and urbanization of 285 prefecture-level cities or above in China from 2006 to 2015 by use the coupled coordination model, spatial autocorrelation and geographical detector method. Research shows that: 1) The overall level of infrastructure and urbanization in the prefecture-level cities is low, showing a hierarchical structure as the "pyramid". The degree of coupling is relatively small, and it is in the running-in stage. With the spatial and temporal patterns of the eastern China＞the northeast China＞the media China＞the western China, the coordination degree is steadily improved, and the difference between the cities is significant. What is more, moderate disorders of the city accounted for the majority. 2)Spatial distribution characteristics are also significant, formed with a hotspot with Yangtze River Delta, Pearl River Delta and a cot point area with Qingling-Bashan mountainous region, Sichuan Basin. 3) The spatial differentiation of the level of coordination between infrastructure and urbanization is mainly driven by economy, policy regulation and location traffic.