Abstract: Knowledge and technology are important characterizations of technological innovation. Sino-US scientific & technological competition and cooperation have become the hotspot and frontier of world economic geography. We integrates data excavation, knowledge measurement, social network and GIS spatial analysis methods in this paper. From the three dimensions of paper collaboration, patent cooperation and patent transaction, we describe the spatial evolution of Sino-US scientific & technological cooperation network: (1) Cities participating in bilateral scientific and technological cooperation between China and the United States continue to grow, but American cities still occupy a dominant position；(2) The cities participating in scientific and technological cooperation are those with more research institutes and stronger innovation capabilities, and this pattern maintains time inertia and spatial flexibility; (3) The spatial distribution of paper and patent cooperation is relatively scattered, while the transfer of patent has significant spatial agglomeration and is highly concentrated in a few science& technology innovation centers; (4) The hub cities of science & technology innovation and cooperation in China are highly concentrated in the southeast coast, Hong Kong and Macao, while the United States has obvious contact diffusion characteristics; (5) The urban science & technology cooperation between China and US is shifting to a reticular structure. The paper collaboration network evolute from three-core to quad-core. More cities participating in patent cooperation, and highly dependent on individual hub cities; (6) China more depend on the patent of US，and it continues to deepen; while the United States is the opposite.