Abstract: On the basis of reconstructing urban space hierarchy of the gateway cities in Chengdu-chongqing Economic Zone with system clustering method（HCA）, and using improved gravity model to analyze the Chengdu-chongqing dual-core metropolitan area space radiation effect on eight gateway cities in economic zone and applying the theory of location entropy respectively advantage of leading industry distribution situation of the gateway cities, the study found that: the industrial spatial layout of Chengdu-chongqing Economic Zone has possessed double leading share form, and industrial transfer mechanism supported by traditional policy area should be gradually replaced with economic zones and cities. Industry accept order of Chengdu-chongqing Economic Zone should be confirmed by urban space hierarchy and space gravitational radiation level. And now industry accept order has been in line with the industrial spatial gradient transfer conditions under the condition of large market.