Abstract: The prevalence of e-shopping has raised concern that traditional in-store shopping might be replaced by e-shopping because of its potential for saving shopping travel and supporting sustainability on both local and global scale. Recent studies have examined what factors affect peoples' preference for e-shopping in developed countries. Yet to date exploration of the impact of space-time constraints on people's e-shopping behaviour in the context of China’s fast increasing share of on-line consumption from geographical perspective is rare. In light of this, this paper based on space-time constraints theory which is emphasized by time geography, taking the Chinese metropolis Nanjing as a case, usage of questionnaires and activity/travel diary data, examines the factors affecting the frequency of e-shopping in Nanjing from the perspective of space-time constraints. The results show: ① Female between 26-30 years old holding bachelor or higher degree and with personal monthly income of 2000-3000 Yuan shows high likelihood of online buying; ② Home internet accessibility, years of experience in internet use and frequency of using internet positively affect residents' intention as well as action to buy online；③People with lower accessibility to local in-shopping sites and more working hours are more likely to engage in e-shopping. The underlying explanation is that e-shopping improves shopping efficiency and removes the distance constraint. Given the spatial residence distribution, it can be inferred that the prosperity of e-shopping is expected to reduce car travel in the suburb areas of Nanjing. This paper offer guide for the future orderly e-shopping behaviour of Nanjing residents and make recommendations for sustainable travel.