Abstract: This paper studies the space-time evolution of geographic agglomeration of Urumqi’s manufacturing , based on the economic census data of 2004,2008 and 2013 and uses the locational Gini coefficient , hot spot analysis, kernel density analysis and exploratory spatial data analysis. Results suggest: (1)From 2004 to 2013, the overall agglomeration degree in Urumqi’s manufacturing industry significantly increases and the agglomeration degree shows that new technology industry> Machinery and equipment industry> Basic industry> Urban industry. (2)The manufacturing industry enterprises of Urumqi spread from central area to the direction of northeast and northwest, the degree of concentration of the center gradually weakened, the scope of agglomeration constantly expanded. The spatial structure mode is gradually changing from the single-core model to multi-core model. (3)From 2004 to 2013, the scope of urban industrial distribution has been expanded, and it tend to Outward diffusion; the new technology industry always concentrated in center area, location change is not obvious; the machinery and equipment industry and basic industry have obvious location change ,they spread and transferred from center area to suburban district and the outer suburbs, they are the main driving force for the formation and evolution of the spatial pattern of manufacturing industry.(4) The spatial and temporal pattern evolution of manufactruring industry in Urumqi is the result of the common function of market and government.