Abstract: Innovation gradually replaces capital and becomes a new driving force for regional development in the new era. Germany has been leading the world in scientific and technological innovation, with obvious advantages in regional development system. On the basis of understanding the history and current situation of German innovation development, this paper combs the characteristics of German innovation policy. Firstly, in terms of guiding ideology, it bid farewell to the old era of beggaring neighbors, opened a new era of taking neighbors as companions and being consistent with the outside world, bid farewell to the old era of greater scale and opened a new era of innovation; The old era of cost reduction opens a new era of attracting talents; secondly, in specific measures, various ways should be taken simultaneously to provide scientific and technological capital support; ‘top-down’ and ‘bottom-up’ should be combined to promote the development of innovation clusters; and technological intermediary service institutions should be the core to activate technological diffusion and innovation activities. Although China and Germany are at different stages of economic development, Germany's experience in high level design of innovation, ‘threshold’ research, open regional innovation system and construction of innovation alliance deserves our reference.