Abstract: With the acceleration of industrialization, urbanization and global integration, the connection between cities is becoming increasing intimate, which plays an important role in regional economic growth. “Four-city Area in Middle China” enjoys a nature areal association, together with favorable economic situation, policy guarantee, convenient traffic network and solid foundation of linkage co-building. Taking core cities in “Four-city Area in Middle China” as study objects, the author made a judgment of competitive industries in each city by using location quotient, figured out the extroversion degree through some indexes, such as urban flows, and then measured the traffic development situation according to comprehensive traffic accessibility. Several conclusions can be drew from the paper: firstly, industry development in four cities have their characters respectively but an industry convergence still exists; secondly, Changsha holds the highest extroversion degree; thirdly, Wuhan is equipped with the best traffic accessibility, with Hefei and Nanchang stand at the end of “Four-city Area in Middle China”, although both of them have an outward-looking economic system and comprehensive transportation system. Based on these, the author suggested that strengthen the spatial connection and promote city construction of “Four-city Area in Middle China” could be a practical support for implementing the rising strategy of Central China.