Abstract: Taking 26 cities of Yangtze River Delta Urban Agglomeration as the research objects, this article analyzed the tourism economy regional disparities from the perspective of time and space and its influence factors, the conclusions are as follows: From 2008 to 2015, the absolute disparity of tourism economy expanded and the relative disparity narrowed; Inter—province disparity and disparity within cities of different grades were the main contributor to the regional disparity of tourism economy; The development of tourism economy was low in most cities, and the core—periphery structure was the main characteristic of regional tourism economy development; The main causes of tourism economy disparity included resource endowments、the level of economic development and industrial structure.