Population, economy and agro-ecological environment are important contents for the sustainable development of mountain areas. This paper selects the data of population, economy and agro-ecological environment of Wumeng Mountain, Guizhou Province, and measures the development trend of population, economy and agro-ecological environment by entropy method, coupling degree, coordination degree, and further explores its coupling degree and coordination trend. The research draws the following conclusions: (1) Between 2005 and 2015, the population and economic development of Wumen Mountain, Guizhou Province were generally better, and the development of agro-ecological environment was lagging behind. During the period, Ipopand Iecoincreased by 0.259 and 0.487 respectively, and Iagr decreased by 0.398. (2) From 2005 to 2015, the relationship between population, economy and agro-ecological environment in Wumen Mountain, Guizhou Province is becoming closer and closer, and the overall coordination is increasing, but the degree of system coordination is significantly lower than that of coupling. System development is an uneven development. (3)From 2005 to 2015, there was a spatial difference in the coordination of population, economy and agro-ecological environment in Wumen Mountain, Guizhou Province, which was generally high in the east and low in the west. The coordination levels of the Qixinguan, Chishui and Xishui were higher. (4) In 2005-2015, the coupling degree of Wumeng Mountain, Guizhou Province was upgraded to the advanced coupling stage, but most counties and districts are still in the primary coordination stage.