Geo-setting provides sufficient theoretical support for understanding the evolution of the situation of a country or region, and its risk research has the advantages of cross-integration. Accurately identifying and scientifically preventing geo-setting risks is of great significance to safeguarding China's overseas interests. By clarifying the relationship between geo-setting and risk, the concept of geo-setting risk was proposed. An assessment model of geo-setting risks was established based on geo-potential and the theories and methods of geo-setting. Taking Southeast Asia and South Asia as examples, this paper conducted spatial identification of geo-setting risks faced by China in this region and explored their spatio-temporal differentiation rules. The results show that: ① The geo-setting risks faced by Laos, Nepal, Maldives, Brunei, Pakistan and Myanmar are mainly affected by the country's vulnerability; in Singapore and India, they are mainly affected by risk resilience and geopolitical potential ratio; in Vietnam, they are affected by the above three factors; and in the other nine countries, they are mainly affected by geopolitical potential ratio and risk resilience. ② China's geo-setting risks in Southeast Asia and South Asia show a fluctuating downward trend, showing a trend of low in Southeast Asian countries, high in South Asian countries, and lower in the Indochina Peninsula than in neighboring countries in the South China Sea. ③ The geo-setting risks in Laos, Nepal, Brunei, Maldives, Bhutan, Sri Lanka, Malaysia and Singapore are low risks. Afghanistan, the Philippines and India, where the game between major powers is more intense, are high risks. Pakistan and Myanmar, where the internal situation is relatively chaotic, are medium-high risks. The other five countries are medium risks. In the future, it is necessary to enhance national competitiveness at the domestic level, optimize the ability of risk research and judgment, strengthen inter-governmental communication at the international level and pay attention to the geographical environment of the host country, so as to serve the maintenance of China's overseas interests.